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1、NMN 是什么?

烟酰胺单核苷酸(Nicotinamide mononucleotide,NMN)是维生素 B3(烟酰胺)的一种衍生物,分子量为 334.221g/mol。NMN 存在两种差向异构体:α型和β型。研究发现,只有 β型NMN具有生物活性。

 全酶催化法定向合成β-烟酰胺单核苷酸,高活性原料。


2、昊邦NMN规格

β-烟酰胺单核苷酸(NMN)

分子式 C11H15N2O8P

分子量 334.2

CAS No.:1094-61-7


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3、NMN 的安全性验证

2016年日本开展人体期临床一期实验,主要验证安全;

2017年日本开展人体期临床实验二期临床实验;

2019年12月日本宣布NMN每日补充500mg是安全性;

2020年,NMN已被日本厚生省允许在食品中添加

 

NMN 安全毒理实验已进行

1,急性经口毒性试验

2,90天大鼠经口毒性试验

3,致畸试验

4,遗传毒性试验(三项)

5,FDA 注册备案

6,FDA GRAS 自认证....(昊邦证书)正在进行中.

7,与美国ULCA合作

8,其他国家的资质....(昊邦证书)正在进行中.


4、NMN 现有的科普文献

1.提高NAD+ 水平

《Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging[J]. Cell, 2013》

2. 激活 SIRTUINS 

《Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases》

3. 修复 DNA 损伤 

《 A conserved NAD+ binding pocket that regulates protein-protein interactions during aging[J]. Science》

4. 支持新陈代谢,促进能量产生 

《Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3‐dependent mechanism in male mice》

5. 促进血管再生、保持血管弹性,增强耐力和活力 

《Impairment of an Endothelial NAD+- H2S Signaling Network Is a Reversible Cause of Vascular Aging[J]. Cell》

6. 帮助体重管理 

《Head to head comparison of short-term treatment with the Nad+ precursor nicotinamide mononucleotide (NMN) and 6 weeks of exercise in obese female mice》

7. 促进心脏健康 

《Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and Reperfusion》

8. 促进大脑健康 

《Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, antiinflammatory, and anti-apoptotic effects[J]. Geroscience》

9. 改善胰岛素敏感性 

《Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice[J]. Cell metabolism》

10. 防止骨密度下降、改善视力和免疫功能等 

《Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice[J]. Cell Metabolism》

11. NMN逆转了雌性动物卵子的衰老,提高胚胎发育和活产率

《NAD+ Repletion Rescues Female Fertility during Reproductive Aging》

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